Design and Evaluation of Natamycin Nanocrystals Loaded In Situ Gel for Ophthalmic Administration
نویسندگان
چکیده
Background: Natamycin belongs to a large group of naturally occurring polyene antifungal antibiotics derived from Streptomyces natalensis. has restrictive pharmaceutical role because its extremely low aqueous solubility, which severely reduces the bioavailability drug. To improve absorption drug, nanocrystals natamycin were prepared and incorporated into in situ gel.
 Aim: solubility by preparing nanocrystal gel for ophthalmic delivery
 Methodology: was using Sono-Precipitation method. Box-Behnken approach employed assess influence independent variables, namely concentration stabilizer, sonication time amplitude on particle size zeta potential nanocrystal.
 Optimized formulations characterized various parameters like pH, viscosity, drug content, vitro release ex vivo permeation studies.
 Results: The optimized formulation with 293.9nm -14.6mV gels. pH triggered Carbopol Hydroxypropyl methylcellulose (HPMC)., showed clear preparation, closed tear fluid, i.e., 7.4, viscosity pseudoplastic behaviour immediate gelation remained an extended period, content around 99.70%. From characterizations given above, PF-4 evaluated In showing slow sustained when compared marketed followed first-order kinetics diffusion-controlled mechanism. Ex through goat's cornea better than formulation. stability studies that stable at appropriate condition.
 Conclusion: Nanocrystals successfully formulated Further need be carried out confirmation pharmacological activity
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ژورنال
عنوان ژورنال: Journal of pharmaceutical research international
سال: 2021
ISSN: ['2456-9119']
DOI: https://doi.org/10.9734/jpri/2021/v33i38a32090